Preparation of N-hydroxyazoles by oxidation of azoles
Authors:
- Mikael BegtrupMBMikael Begtrup
- Per VedsøPVPer Vedsø
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 243-247
Abstract
Azoles without N-substituents are oxidized with per-acids or perborate to the corresponding N-hydroxy substituted azoles. 1,2,4-Triazole and tetrazole produce two isomers separated through their O-benzyl derivatives. Imidazole and 1,2,3- and 1,2,4-triazole can be di-oxygenated in low yields. N-Hydroxypyrazole is deoxygenated by per-acid.Keywords
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