Toward the Rational Design of p53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant
Authors:
- Joel L. KaarJoel L. Kaar
- Giovanni SettanniGiovanni Settanni
- Andreas C. JoergerAndreas C. Joerger
- Alan R. FershtAFAlan R. Fersht
- 1 January 2010
- journal article
- research article
- Published by Elsevier in Chemistry & Biology
- Vol. 17 (1) , 46-56
Abstract
No abstract availableKeywords
This publication has 57 references indexed in Scilit:
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular SimulationJournal of Chemical Theory and Computation, 2008
- p53 in health and diseaseNature Reviews Molecular Cell Biology, 2007
- Impact of mutant p53 functional properties onTP53mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 databaseHuman Mutation, 2007
- Structural basis for understanding oncogenic p53 mutations and designing rescue drugsProceedings of the National Academy of Sciences, 2006
- Scalable molecular dynamics with NAMDJournal of Computational Chemistry, 2005
- Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compoundNature Medicine, 2002
- All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of ProteinsThe Journal of Physical Chemistry B, 1998
- VMD: Visual molecular dynamicsJournal of Molecular Graphics, 1996
- The p53 tumour suppressor geneNature, 1991
- CHARMM: A program for macromolecular energy, minimization, and dynamics calculationsJournal of Computational Chemistry, 1983