Heparin Pharmacokinetics and Pharmacodynamics
Author:
- 1 May 1992
- journal article
- review article
- Published by Springer Nature in Clinical Pharmacokinetics
- Vol. 22 (5) , 359-374
Abstract
Heparin was discovered approximately 75 years ago and has been used extensively for the last 50 years to treat thromboembolic disorders. An endogenous glycosaminoglycan, heparin is found largely in...Keywords
This publication has 95 references indexed in Scilit:
- The Antithrombotic Activity and Pharmacokinetics of Enoxaparine, A Low Molecular Weight Heparin, In Humans Given Single Subcutaneous Doses of 20 to 80 mgThe Journal of Clinical Pharmacology, 1988
- Continuous Intravenous Heparin Compared with Intermittent Subcutaneous Heparin in the Initial Treatment of Proximal-Vein ThrombosisNew England Journal of Medicine, 1986
- Pharmacokinetics of Intravenously and Subcutaneously Administered Fragmin in Healthy VolunteersPathophysiology of Haemostasis and Thrombosis, 1986
- Pharmacokinetic Studies of Standard Heparin and Low Molecular Weight Heparin in Patients with Chronic Renal FailurePathophysiology of Haemostasis and Thrombosis, 1986
- Increased Anti-Xa Bioavailability for a Low Molecular Weight Heparin (PK 10169) Compared with Unfractionated HeparinSeminars in Thrombosis and Hemostasis, 1985
- Kinetics of technetium-labeled heparin in thromboembolism: Preliminary reportInternational Journal of Nuclear Medicine and Biology, 1979
- Heparin therapy: A randomized prospective studyAmerican Heart Journal, 1979
- Anticoagulant activity of heparin: Separation of high‐activity and low‐activity heparin species by affinity chromatography on immobilized antithrombinFEBS Letters, 1976
- Heparin kinetics in venous thrombosis and pulmonary embolism.Circulation, 1976
- The separation of active and inactive forms of heparinBiochemical and Biophysical Research Communications, 1976