Influences of Aging and Dietary Restriction on Serum Thymosin l Levels in Mice

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Abstract
Influences of age (3 wk, 2, 7, 19, or 26 mo), long-term dietary restriction (DR) started at 3 wk of age, and acute fasting state on serum thymosinαl (Tαl) levels were measured by radioimmunoassay in female mice from a long-lived strain. The average Tαl level was highest (∼60 ng/ml) at 3 wk and fell sharply such that 2 mo old mice fed either normal (N, ∼80% of ad libitum intake) or restricted (R, ∼50% of ad libitum intake) diets averaged ∼20 ng/ml. Any agerelated declines after 2 mo of age were mild and statistically significant only for R mice bled 2–4 h (but not 24–48 h) post-feeding. Tαl levels were lower in group R than in group N mice in one experiment at 19 mo of age but not in another at 26 mo. The decline with age in serum Tαl levels is mainly a very early life event for mice of this hybrid strain and appears uninfluenced by DR. Tαl levels are variably reduced by DR later in life.

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