Interactions of β-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease
- 1 September 2017
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Hematology
- Vol. 24 (5) , 427-431
Abstract
Purpose of review: To review the evidence that the Alzheimer peptide β-amyloid interacts with the blood coagulation system and influences the pathophysiology of the disease. Recent findings: β-amyloid can interact with fibrinogen and blood coagulation factor XII and trigger ischemia and inflammation. Summary: β-amyloid interacts with fibrinogen and factor XII. These interactions can lead to increased clotting, abnormal clot formation, persistent fibrin deposition, and generation of proinflammatory molecules. These events can damage neurons and could contribute to the cognitive decline in Alzheimer's disease patients.Keywords
This publication has 54 references indexed in Scilit:
- Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrinBlood, 2012
- Factors affecting Aβ plasma levels and their utility as biomarkers in ADNIActa Neuropathologica, 2011
- Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?Experimental Gerontology, 2011
- Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerizationProceedings of the National Academy of Sciences, 2010
- Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's DiseaseNeuron, 2010
- Fibrinogen signal transduction in the nervous systemJournal of Thrombosis and Haemostasis, 2009
- Peripheral Aβ subspecies as risk biomarkers of Alzheimer's diseaseProceedings of the National Academy of Sciences, 2008
- Misfolded proteins activate Factor XII in humans, leading to kallikrein formation without initiating coagulationJournal of Clinical Investigation, 2008
- Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosisBlood, 2008
- Amyloid-β Peptides Interact with Plasma Proteins and Erythrocytes: Implications for Their Quantitation in PlasmaBiochemical and Biophysical Research Communications, 2000