N-Acetylneuraminic Acid: Neoglycoproteins and Pseudopolysaccharides
Authors:
- 1 March 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 6 (1) , 161-165
Abstract
A simplified procedure for the synthesis of acetochloroneuraminic acid is described starting from the methyl ester. N-acetyl neuraminic acid α-allyl glycoside was prepared in high yield using silver salicylate as catalyst. Reductive ozonolysis of the allyl group, followed by direct reductive ami nation to protein carriers, gave immunogenic neoglycoproteins. Copolymerization of the α-allyl glycoside with acrylamide produced a water-soluble pseudopolysaccharide useful for the EL ISA technique.Keywords
This publication has 16 references indexed in Scilit:
- Synthesis and conformational studies of 2-β-chloro, 2-α-fluoro, and 2-β-fluoro derivatives of 2-deoxy-N-acetyl-neuraminic acidCarbohydrate Research, 1984
- Synthese eines trisaccharides aus N-acetylneuraminsäure und N-acetyllactosaminCarbohydrate Research, 1984
- Capsular Polysaccharides as Human Vaccines1983
- A facile preparation of alkyl α-glycosides of the methyl ester of N-acetyl-d-neuraminic acidCarbohydrate Research, 1982
- Sialic Acids1982
- Cell surface carbohydrates for targeting studiesCanadian Journal of Chemistry, 1980
- A new approach to the synthesis of 5-N-acetyl-D-neuraminic acid α-ketosidesCarbohydrate Research, 1980
- Carbon-13 nuclear magnetic resonance spin-lattice relaxation in the N-acylneuraminic acids. Probes for internal dynamics and conformational analysisJournal of the American Chemical Society, 1977
- A new and convenient method for converting olefins to aldehydesTetrahedron Letters, 1966
- Synthese anomerer Sialinsäure‐methylketosideEuropean Journal of Inorganic Chemistry, 1966