A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA
Authors:
- D KochDKD Koch
- R SircarRSR Sircar
- C HeuserCHC Heuser
- V DiehlVDV Diehl
- W KruisWKW Kruis
- C PohlCPC Pohl
- H AbkenHAH Abken
- 1 February 1999
- journal article
- Published by Springer Nature in Gene Therapy
- Vol. 6 (2) , 300-304
Abstract
At the forefront of medicine, Gene Therapy brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes Progress & Prospects reviews and News and Commentary articles, which highlight the cutting edge of the field.Keywords
This publication has 15 references indexed in Scilit:
- Can combined T-cell- and antibody-based immunotherapy outsmart tumor cells?Immunology Today, 1998
- Binding Reactivity of Monoclonal Anti-Carcinoembryonic Antigen (CEA) Antibodies with Cell Membrane-Bound CEA and with Free CEA in SolutionImmunological Investigations, 1996
- The T-body approach: potential for cancer immunotherapySpringer Seminars in Immunopathology, 1996
- Cytotoxic T lymphocytes with a grafted recognition specificity for ERBB2-expressing tumor cells.Proceedings of the National Academy of Sciences, 1994
- Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.Journal of Experimental Medicine, 1993
- Characterisation of a humanised bispecific monoclonal antibody for cancer therapyBritish Journal of Cancer, 1993
- Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.Proceedings of the National Academy of Sciences, 1993
- Endowing T cells with antibody specificity using chimeric T cell receptorsThe FASEB Journal, 1992
- Carcinoembryonic AntigenAnnals of Internal Medicine, 1986
- Immunohistochemical localization and molecular characteristics of three monoclonal antibody‐defined epitopes detectable on carcinoembryonic antigen (CEA)International Journal of Cancer, 1985