PATTERN EVOKED-POTENTIAL MEASUREMENTS SUGGESTING LATERALIZED HEMISPHERIC DYSFUNCTION IN CHRONIC-SCHIZOPHRENICS

Authors:
  • RRR A Roemer
    R A Roemer
  • CSC Shagass
    C Shagass
  • JSJ J Straumanis
    J J Straumanis
  • MAM Amadeo
    M Amadeo
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  • 1 January 1978
    • journal article
    • research article
    • Vol. 13  (2) , 185-202
    • PMID:667227
Abstract
Visual evoked potentials (VEP) were measured to obtain evidence concerning possible lateralized hemispheric dysfunction in schizophrenia. The main results were based on the spatial distribution (12 electrodes) of a measure of VEP wave form stability over time. Subjects were 86 psychiatric inpatients and 33 nonpatients; these were grouped in 3 ways to permit comparisons of various age- and sex-matched diagnostic classes. VEP wave form stability was generally lower in all types of schizophrenia than in nonpatients, nonpsychotic patients and probably, psychotic depressives. VEP stability differed more between the hemispheres in schizophrenics and psychotic depressives than in nonpsychotic subjects; in schizophrenics, left hemisphere stability was lower than normal, whereas it was normal in psychotic depressives. VEP stability differences between the hemispheres were also greater than normal in latent schizophrenics, with less stability on the left. A direct demonstration of a left hemisphere involvement in schizophrenic dysfunction was provided.

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