One-Pot Synthesis of Biologically Important Spiro-2-amino-4H-pyrans, Spiroacenaphthylenes, and Spirooxindoles Using DBU as a Green and Recyclable Catalyst in Aqueous Medium
- 5 September 2013
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 43 (24) , 3239-3246
Abstract
We have reported DBU-catalyzed one-pot synthesis of biologically and pharmacologically important spiropyrans from condensation of malononitrile/ethyl cyanoacetate, 1,3-dicarbonyl compounds, and ninhydrin/acenaphthequinone/istain in good yields. This new protocol employing DBU, which is a green, recyclable, and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction times, and easy isolation of products. The structures have been confirmed by x-ray analysis. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]Keywords
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