THE SYNTHESIS OF POSSIBLE DEGRADATION PRODUCTS OF METATHEBAINONE. II.

Authors:
  • HHH. L. Holmes
    H. L. Holmes
  • LTL. W. Trevoy
    L. W. Trevoy
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Abstract
The poor yield of β-(3,4-dimethoxybenzoyl)-propionic acid obtained from the condensation of equimolar quantities of veratrole and succinic anhydride by two moles of aluminium chloride is due to the demethylation of the C4-methoxyl group. The phenolic acid has been isolated and its structure established by degradation to 3-methoxy-4-ethoxybenzoic acid. The yield of the dimethoxy-acid has been improved to 83% by modifying the usual procedure for this reaction.