Dose- and strain-dependent effects of dermorphin and [D-Ala-2-D-Leu-5]enkephalin on passive avoidance behavior in mice.
Authors:
- Claudio CastellanoCCClaudio Castellano
- Flaminia PavoneFPFlaminia Pavone
- 1 January 1985
- journal article
- research article
- Published by American Psychological Association (APA) in Behavioral Neuroscience
- Vol. 99 (6) , 1120-1127
Abstract
Dermorphin and [D-Ala2-D-Leu5]enkephalin, administered intracerebroventricularly (icv) immediately after training in a passive avodiance test, exerted dose- and strain-dependent effects in DBA/2 (DBA) and C57BL/6 (C57) mice. In fact, the peptides impaired, at a low dose (5 ng), the retention performances of both strains; a higher dose (50 ng) impaired retention in DBA but improved it in C57 mice. A dose of naloxone (0.3 .mu.g, icv), which was ineffective when administered alone, antagonized the effects observed. The results are discussed in terms of strain differences in central mechanisms.Keywords
This publication has 2 references indexed in Scilit:
- Opposite effects of met-enkephalin and leu-enkephalin on a discriminated shock-escape task.Behavioral Neuroscience, 1984
- Behavioural data on dermorphins in miceEuropean Journal of Pharmacology, 1982