Drift and conservation of differential exon usage across tissues in primate species
Open Access
- 3 September 2013
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 110 (38) , 15377-15382
Abstract
Significance: In higher organisms, most genes consist of several disconnected regions (exons), which are combined in various ways to produce several different gene transcripts from the same gene. Such alternative exon usage is thought to contribute to the ability of organisms to generate different cell types and tissues from a single genome. However, recent evidence has also suggested that much alternative exon usage might be noise with no particular function. We reconcile these two views by comparing how exons are used in different tissues and for which exons these usage patterns across tissues change or stay similar (are “conserved”) in several primate species. The latter case is an indication that the pattern is of functional importance, and our analysis quantifies how widespread such cases are.Keywords
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