High antigen concentration inhibits T cell proliferation but not interleukin 2 production: Examination of limiting dilution microcultures and T cell clones
Authors:
- 1 January 1986
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 16 (1) , 30-34
Abstract
The effect of high antigen dose on the activation of cytochrome c peptide‐primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide‐specific T cells was completely inhibited at high antigen concentration in C57BL/6 but only partially in DBA mice and had no effect in SJL mice. Clones derived from DBA mice showed a differential capacity to be inhibited by high antigen dose. On the other hand, interleukin 2 moduction by these clones was not impaired regardless of the antigen concentrations used.Keywords
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