VisR Ultrasound Improves Diagnosis of Breast Cancer by the Elastogram-to-B-Mode Ratio in a Blinded Reader Study

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Abstract
Ultrasound elastography is increasingly being used alongside mammography for breast cancer diagnosis, particularly in women with radiographically dense breasts. The elastogram-to-B-Mode ratio (E/B), which compares lesion sizes in B-Mode and stiffness images, has been shown to differentiate malignant (E/B >1) from benign (E/B 1 in malignant lesions and <1 in benign lesions) to those observed in stiffness images. Additionally, E/B values calculated from RE alone, RV alone, or a combination of RE and RV achieved 4-16% higher AUCs for discriminating malignant lesions compared to E/B derived solely from Acoustic Radiation Force Impulse (ARFI) peak displacement. These results suggest that incorporating VisR-derived viscosity and elasticity metrics into E/B calculations could significantly improve diagnostic accuracy for breast cancer detection.
Funding Information
  • National Institutes of Health (R01CA281150)
  • National Institutes of Health (R01HL092944)
  • National Institutes of Health (R01DK107740)
  • University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center Pilot Development
  • Provost’s Doctoral Fellowship at North Carolina State University

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