Forecasted trends of the new COVID-19 epidemic due to the Omicron variant in Thailand, 2022

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Abstract
Background The introduction of the Omicron variant is of significant concern to the Thai Government due to the possibility of a new wave of the COVID-19 epidemic, which may cause a huge strain to the country’s health system. This study aims to forecast the trends of COVID-19 cases and deaths given the advent of the Omicron variant in Thailand. Methods We used a compartmental susceptible-exposed-infectious-recovered model in combination with a system dynamics model. We developed four scenarios according to differing values of the production number (R) and varying vaccination rates. Results The findings indicated that in the most pessimistic scenario (R = 7.5 and base vaccination rate), the number of incident cases reached a peak of 49,523 (95% CI: 20,599 to 99,362) by day 73 and the peak daily deaths enlarged to 270 by day 50 (95% CI: 124 to 520). The predicted cumulative cases and deaths at the end of the wave (day 120) were approximately 3.7 million and 22,000 respectively. In the most optimistic assumption (with R = 4.5 and a speedy vaccination rate [tripled the base rate]), the peak of the incident cases was about one third of the most pessimistic assumption (15,650, 95% CI: 12,688 to 17,603). The corresponding daily fatalities were 72 (95% CI: 54 to 84) and the prevalent intubated cases numbered 572 (95% CI: 429 to 675). Conclusions In the coming months, Thailand may face a new wave of the COVID-19 epidemic due to the Omicron variant. The case toll due to the Omicron wave is likely to outnumber the earlier Delta wave, but the death toll is proportionately lower. Despite the immune-escape characteristic of the Omicron variant, the vaccination campaign for the booster dose should be expedited as an effective way of preventing severe illness and death.
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