Supplementary Figure 4 from The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib

Authors:
  • LMLaetitia Marzi
    Laetitia Marzi
  • MGMelanie Gordon
    Melanie Gordon
  • ZOZoe Weaver Ohler
    Zoe Weaver Ohler
  • SSShyam K. Sharan
    Shyam K. Sharan
  • MBMichael L. Beshiri
    Michael L. Beshiri
  • MEMoudjib Etemadi
    Moudjib Etemadi
  • JMJunko Murai
    Junko Murai
  • KKKathleen Kelly
    Kathleen Kelly
  • YPYves Pommier
    Yves Pommier
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Abstract
Antitumor activity and toxicity of the indenoisoquinolines LMP400, LMP744 and LMP776 in Brca1-deficient murine orthotopic allograft model for ovarian cancer and synergy of LMP400 with olaparib. A-C. Antitumor activity of LMP400, LMP744, LMP776, olaparib alone and olaparib combination with LMP400 represented as tumor volume changes in individual mice. Single treatment experiment (A) and Combination study (C). B-D. Mice Body Weight changes for the corresponding experiments. Single treatment experiment (B) and Combination study (D).