Peripheral refraction, relative peripheral refraction, and axial growth: 18‐month data from the randomised study—Clinical study Of Near‐sightedness; TReatment with Orthokeratology Lenses (CONTROL study)

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Abstract
Purpose: To investigate changes in peripheral and relative peripheral refraction (RPR) during orthokeratology lens (OKL) use in children, and predictors for myopia progression in a randomized controlled trial.Methods: Refraction and axial length (AL) were measured at baseline, 6, 12, and 18 months for children aged 6–12 years, with myopia of 0.5 to 4.75 dioptres (D) spherical component randomized to either OKL or single‐vision spectacles (SVS) at baseline. Cycloplegic spherical equivalent refractive error (SEQ) was measured on‐axis and eccentric at 10°, 20°, and 30° during nasal and temporal gaze in the horizontal plane with Shin‐Nippon Nvision‐K 5001. RPR was computed as SEQ(eccentricity) minus SEQ(on axis). AL was measured with Lenstar LS900.Results: Twenty‐one and 28 subjects from the OKL and SVS groups, respectively were available for analysis. OKL wear induced significant myopic RPR at all eccentricities (p ≤ 0.004) whereas peripheral refraction only changed in two out of six eccentric measuring points. Baseline peripheral refraction SEQ at all eccentricities, baseline on‐axis SEQ, and baseline RPR at 30° nasal eccentricity were positively correlated to treatment efficacy defined as change in AL.Conclusion: We found no correlations between change in RPR and treatment efficacy defined as change in AL. Interestingly, our results suggest that the central emmetropisation that occurs during OKL‐use accounts for most of the optical changes and to a lesser extent the mid‐peripheral plus‐zone of the lens.
Funding Information
  • Fight for Sight UK (2017:17, 2018:23, 2019:21)
  • Gangstedfonden (A33352)

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