Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity.
Authors:
- Yuji NishiyamaYNYuji Nishiyama
- Shinichi OhtaSOShinichi Ohta
- Hideo KameiHKHideo Kamei
- Masataka KonishiMKMasataka Konishi
- Takeo MiyakiTMTakeo Miyaki
- Toshikazu OkiTOToshikazu Oki
- Hiroshi KawaguchiHKHiroshi Kawaguchi
- 1 January 1988
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 41 (10) , 1331-1337
Abstract
New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.Keywords
This publication has 2 references indexed in Scilit:
- Glidobactins A, B and C, new antitumor antibiotics. II. Structure elucidation.The Journal of Antibiotics, 1988
- Structure-activity relationships of anthracyclines relative to cytotoxicity and effects on macromolecular synthesis in L1210 leukemia cells.The Journal of Antibiotics, 1981