Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter
Authors:
- 19 July 2022
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 66 (7) , e0006222
Abstract
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO 2 ) and albendazole 2-aminosulphone (ABZSO 2 -NH 2 ).Keywords
Funding Information
- Ministerio de Educación y Formación Profesional (FPU18/01559, FPU19/04169)
- Ministerio de Ciencia, Innovación y Universidades (BES-2016-077235)
- Ministerio de Ciencia, Innovación y Universidades (AGL2015-65626-R, RTI2018-100903-B-I00)
This publication has 59 references indexed in Scilit:
- Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: Effect on plasma and milk levels of danofloxacin in sheepThe Veterinary Journal, 2013
- The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRPAntimicrobial Agents and Chemotherapy, 2012
- Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectinJournal of Veterinary Pharmacology and Therapeutics, 2010
- Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazoleBritish Journal of Clinical Pharmacology, 2009
- Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)World Journal of Gastroenterology, 2009
- Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout miceAdvanced Drug Delivery Reviews, 2009
- Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheepJournal of Veterinary Pharmacology and Therapeutics, 2006
- Comparison of milk residue profiles after oral and subcutaneous administration of benzimidazole anthelmintics to dairy cowsAnalytica Chimica Acta, 2005
- Echinococcus multilocularis Alkaline Phosphatase as a Marker for Metacestode Damage Induced by In Vitro Drug Treatment with Albendazole Sulfoxide and Albendazole SulfoneAntimicrobial Agents and Chemotherapy, 2001
- Relative contribution of cytochromes P‐450 and flavin‐containing monoxygenases to the metabolism of albendazole by human liver microsomesBritish Journal of Clinical Pharmacology, 2000