BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Bone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions. In an attempt to provide the basis for guiding research efforts in this field both the more solid and more controversial areas of research were highlighted.
Funding Information
  • People Programme (Marie Curie Actions) of the FP7-2012 (PITN-GA-2012-316549)
  • Ministry of Economy and Competitiveness-MINECO, Spain (SAF2015-69145-R)

This publication has 181 references indexed in Scilit: