Silver-Catalyzed Cascade 1,6-Addition/Cyclization of para-Quinone Methides with Propargyl Malonates: An Approach to Spiro[4.5]deca-6,9-dien-8-ones

Authors:
Publisher website
Google Scholar
Abstract
An unprecedented silver-catalyzed cascade 1,6-addition/5-exo-dig cyclization reaction between para-quinone methides and propargyl malonates under mild reaction conditions has been described. This reaction provides an efficient method to construct versatile spiro[4.5]cyclohexadienones in moderate to excellent yields with high atom economy and scalability.
Funding Information
  • Natural Science Foundation of Jiangsu Province (BK20140655)
  • National Natural Science Foundation of China (21502232, 21572272)
  • State Key Laboratory of Natural Medicines, China Pharmaceutical University (ZZYQ201605)

This publication has 56 references indexed in Scilit: