Synthetic Enzyme‐Catalyzed CO2 Fixation Reactions
Open Access
- 25 February 2021
- journal article
- review article
- Published by Wiley in ChemSusChem
- Vol. 14 (8) , 1781-1804
Abstract
In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2‐fixation cascades.Keywords
Funding Information
- Biotechnology and Biological Sciences Research Council (BB/P000622/1)
- European Research Council (pre-FAB 695013)
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