Greater Impact of Coexistence of Hypertension and Diabetes on Silent Cerebral Infarcts

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Abstract
Background and Purpose— Silent cerebral infarcts (SCIs), often found in the elderly and hypertensives, have been proposed as an indicator of poorer cerebrovascular prognosis. The aim of this study was to evaluate the prevalence and determinants of SCI in hypertensives with or without diabetes mellitus (DM). Methods— We studied 360 asymptomatic hypertensive subjects with or without DM (mean age, 67.4 years; range, 41 to 88 years). We performed 24-hour ambulatory blood pressure (BP) monitoring and brain MRI. The subjects were classified into a diabetic hypertension group with DM (DHT, n=159) or a non-DM hypertension group (non-DHT, n=201). Results— SCIs (presence of ≥1) were found in 82% of the DHT and 58% of the non-DHT ( P P P P Conclusions— Diabetes was the major determinant of SCIs in both SHT and WCHT.

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