Effects of combination of Caiapo® with other plant‐derived substance on anti‐diabetic efficacy in KK‐Ay mice

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Abstract
B. Ludvik et al., have recently shown the effect of Caiapo® (Ipomoea batatas L.) on reducing fasting blood glucose and insulin resistance in type‐2 diabetic patients. It, however, was required 2–4 weeks after the single administration of Caiapo®. The present study aimed to determine if the combination therapy of Caiapo® with a mulberry leaf powder, which inhibits α‐glucosidase, or with a loquat leaf extract, which shows an insulin‐like effect, could make it possible to enhance the antidiabetic activities of Caiapo®, and to shorten the time necessary for the inhibition of increasing blood glucose levels. A mixture of the pulverized tuber of Caiapo® (357 mg/kg) and the mulberry leaf powder (143 mg/kg), or a mixture of the pulverized skin of Caiapo® (194 mg/kg) and the powdered loquat leaf extract (6 mg/kg) was orally administered to 6 weeks‐old male KK‐Ay mice for 28 days and the glucose loading test was conducted every 7 days. In the glucose loading test after one week feeding, a reduction in blood glucose concentration after 60 minutes of the administration of glucose was observed in both mixture groups against the control group (p < 0.05) in the case of Caiapo® only, similar delayed effects were seen in 2–3 weeks after feeding.