Transmission of Cytomegalovirus From Mothers to Preterm Infants by Breast Milk

Authors:
  • CSChyong-Hsin Shu
    Chyong-Hsin Shu
  • NCNan-Chang Chiu
    Nan-Chang Chiu
  • HKHsin-An Kao
    Hsin-An Kao
  • HHHan-Yang Hung
    Han-Yang Hung
  • JCJui-Hsing Chang
    Jui-Hsing Chang
  • CPChun-Chih Peng
    Chun-Chih Peng
  • WHWen-Shyang Hsieh
    Wen-Shyang Hsieh
  • KLKuei-Chen Liu
    Kuei-Chen Liu
  • FHFu-Yuan Huang
    Fu-Yuan Huang
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Abstract
To assess the risk of transmission of cytomegalovirus (CMV) by breast milk from CMV-seropositive mothers to their breast-fed preterm infants and to evaluate their outcome. The study population comprised breast-fed preterm infants with a birth weight of <1500 g and gestational age of <35 weeks. Venous blood samples from the mothers and infants were tested for CMV IgG and IgM antibodies on the 5th and 30th day after birth. Breast milk was obtained for CMV DNA detection by polymerase chain reaction and viral culture on the 5th day and on the 3rd, 6th and 12th week. Urine samples of the babies were collected at the same time for CMV culture. Neurodevelopmental assessment was done at 6 months of age, corrected for preterm birth. Thirty-eight mothers and 42 infants (including 4 sets of twins) were enrolled in the study. A mother-infant pair was excluded because of inadequate breast milk collection. Thirty-six mothers (97.3%) were CMV-seropositive. CMV DNA of breast milk was detected in 35 seropositive mothers. Six infants of 5 mothers were infected (infected group) at a mean of 77 days after birth, and 34 infants of 31 mothers were not (noninfected group). In all the mothers of the infected group, CMV virus could be cultured from the milk whey. The average maternal CMV IgG on day 5 after delivery was higher in the infected than in the noninfected group. Sepsis-like symptoms and hyperbilirubinemia were more frequently noted in the infected infants than in the noninfected, but the difference was not statistically significant. Neurodevelopmental outcome did not significantly differ between the 2 groups. The risk of CMV infection in breast-fed premature infants was highest when the mothers shed viable virus in their breast milk. These mothers had high CMV IgG, which may help identify those mother-infant pairs at risk. Inactivation of the virus in milk by freezing may be a way of reducing the transmission of this virus via breast milk.

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