Levodopa Consumption Reduces Dopaminergic Receptor Responsiveness in Parkinsonʼs Disease
Authors:
- M. R. LuquinM. R. Luquin
- José A. ObesoJOJosé A. Obeso
- 1 August 1989
- journal article
- review article
- Published by Wolters Kluwer Health in Clinical Neuropharmacology
- Vol. 12 (4) , 271-284
Abstract
In seven patients with Parkinson''s disease with daily motor fluctuations, we found that the same subcutaneous apomorphine dose that improved motor function when given in the morning after a normal night without taking levodopa failed to turn patients "on" during afternoone and evening "off" periods, and on a different morning after receiving levodopa during the night. No significant changes in levodopa or 3-O-methyldopa plasma levels that could explain these variations were detected. These findings suggest that increased daily levodopa consumption may reduce striatal responsiveness to dopaminergic stimulation.Keywords
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