Guest Recognition in a Partially Bridged Deep Cavitand
- 5 October 2010
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (21) , 4828-4831
Abstract
The synthesis of a new deep cavitand partially bridged via disulfide bonds is described. Its thermodynamic and kinetic complexation parameters are compared with those of an unbridged analogue. The disulfide bridges cause deviations in ΔH and ΔS but result in only small differences in ΔG of complexation. The bridges increase the activation barrier for guest dissociation and lead to complexes with enhanced kinetic stability.Keywords
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