Evaluation of the Free-Radical Scavenging and Antioxidant Activities of Chilauni,Schima WallichiiKorthin vitro

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Abstract
Aim: Free radicals are an outcome of various metabolic activities and their excess production leads to many diseases. Therefore, it is necessary to neutralize excess free radicals. Materials & methods: Free-radical scavenging activity of various extracts of Schima wallichii was evaluated using standard protocols. Results: Chloroform, ethanol and aqueous extracts of S. wallichii scavenged DPPH, hydroxyl, superoxide, nitric oxide and ABTS free radicals and increased ferric-reducing antioxidant potential in a concentration-dependent manner. A total of 1000 μg/ml of all the extracts and ethanol extract showed highest total flavonoids and phenol contents, respectively. Conclusion: The different extracts of S. wallichii scavenged different free radicals efficiently due to the presence of flavonoids and polyphenols and may be helpful in free radical-induced diseases. Lay abstract Free radicals induce several health disorders including cancer, and their excess generation needs to be controlled. Our study demonstrates that Schima wallichii scavenged DPPH, hydroxyl, superoxide, nitric oxide, ABTS free radicals and increased ferric-reducing antioxidant potential in a concentration-dependent manner. It could be one of the agents able to mitigate excess free-radical generation and ward off free radical-induced inflammation and diseases.
Funding Information
  • University Grants Commission and Department of Biotechnology, Government of India

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