Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy
- 21 July 2026
- journal article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
Abstract
No abstract availableFunding Information
- University Grants Commission
- Anusandhan National Research Foundation (SPR/2023/000358)
- Indian Association for the Cultivation of Science
This publication has 28 references indexed in Scilit:
- Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouseMolecular Therapy Nucleic Acids, 2023
- Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In VitroBioconjugate Chemistry, 2022
- Structural Modifications to the Internal Oligoguanidinium Transporter Uncover Two Potent Analogues that Effectively Deliver the Proapoptotic Peptide in Multiple Cancer Cell LinesBioconjugate Chemistry, 2021
- Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino for NANOG Inhibition to Induce Chemosensitization of Taxol in MCF-7 CellsBioconjugate Chemistry, 2020
- Targeted Delivery of Antisense Oligonucleotides Using Neurotensin PeptidesJournal of Medicinal Chemistry, 2020
- Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA ConjugatesMolecular Therapy, 2018
- Invention and Early History of Morpholinos: From Pipe Dream to Practical Products2017
- Concise Review: NANOG in Cancer Stem Cells and Tumor Development: An Update and Outstanding QuestionsStem Cells, 2015
- Impact of the Guanidinium Group on Hybridization and Cellular Uptake of Cationic OligonucleotidesChemBioChem, 2006
- Morpholino antisense oligomers: the case for an RNase H-independent structural typeBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999