Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

This publication has 10 references indexed in Scilit:

• 1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies
  Bioorganic & Medicinal Chemistry Letters, 2007
• Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors
  Bioorganic & Medicinal Chemistry, 2007
• Chk1 Inhibitors for Novel Cancer Treatment
  Anti-Cancer Agents in Medicinal Chemistry, 2006
• Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
  The EMBO Journal, 2004
• Targeting the checkpoint kinases: chemosensitization versus chemoprotection
  Nature Reviews Cancer, 2004
• Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents
  Journal of Biological Chemistry, 2003
• ATM and related protein kinases: safeguarding genome integrity
  Nature Reviews Cancer, 2003
• Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G ₂ checkpoints
  Proceedings of the National Academy of Sciences, 2002
• Cell cycle checkpoint signaling through the ATM and ATR kinases
  Genes & Development, 2001
• Rapid Destruction of Human Cdc25A in Response to DNA Damage
  Science, 2000