Research on Functional Nutrients and Lipoprotein Quality Evaluation Contributing to a Reduction in Risk Factors for Atherosclerosis

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Abstract
Comprehensive management of a variety of risk factors including dyslipidemia is important for the prevention of atherosclerotic cardiovascular diseases. For the treatment of dyslipidemia as one such representative risk factor, diet therapy is fundamental ahead of drug therapy, and functional foods are also expected to have favorable effects. In the quantitative evaluation of serum lipids, including LDL cholesterol, HDL cholesterol, and triglyceride, a high level of LDL cholesterol is defined as a primary risk factor for atherosclerosis, but many unresolved questions remain as to whether hypertriglyceridemia and a low level of HDL cholesterol can be regarded as residual risk factors beyond the increased LDL cholesterol. For the establishment of better comprehensive management of atherosclerosis risk factors, we have consistently strived to investigate issues related to metabolism and nutrition science, including the improvement of lipid metabolism-related biomarkers using antioxidant substances (vitamin E and carotenoids) and sophisticated methods for quantitative and qualitative measurement of serum lipids. We believe that these efforts and achievements will help to extend healthy longevity in the general population.

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