Tick-Borne Encephalitis Virus-Neutralizing Antibodies in Different Immunoglobulin Preparations

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Abstract
We demonstrate 2 month old, female B10.T(6R) are highly resistant to systemic infection with the KIM5 strain of Yersinia pestis, and that B10.T(6R) mice become susceptible to Y. pestis infection by 5 months of age. In this study, both young (2 month) and middle-aged (5-12 month) B10.T(6R) were infected with equal CFUs of Y. pestis. The LD50 of young B10.T(6R) mice was ∼1.4 × 104 CFU, while middle-aged B10.T(6R) mice exhibited an LD50 of ∼60 CFU. An elevated bacterial burden was found in the spleens of middle-aged mice at 24 and 60 h and in the livers at 60 h postinfection. Immune cell infiltration was greater in the livers of resistant young mice as compared to middle-aged and the susceptible C57BL/6N strain of mice. Unlike susceptible mice, young B10.T(6R) mice did not develop necrotic lesions throughout the liver. Instead livers from young B10.T(6R) mice contained granulomatous-like structures. Immunohistochemical staining of liver sections from these mice at 60 h postinfection revealed that the majority of immune cells present in these structures consisted of neutrophils. These findings suggest that resistance to plague in B10.T(6R) mice correlates with early formation of neutrophilic lesions in the liver.

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