Antineoplastic Agents. 454. Synthesis of the Strong Cancer Cell Growth Inhibitors trans-Dihydronarciclasine and 7-Deoxy-trans-dihydronarciclasine
- 12 June 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 72 (7) , 1279-1282
Abstract
To further pursue the antineoplastic leads offered by our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).Keywords
This publication has 45 references indexed in Scilit:
- Chemistry, Biology, and Medicinal Potential of Narciclasine and its CongenersChemical Reviews, 2008
- Pancratistatin: A natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosisApoptosis, 2005
- Antineoplastic Agents. 527. Synthesis of 7-Deoxynarcistatin, 7-Deoxy-trans-dihydronarcistatin, and trans-Dihydronarcistatin 1Journal of Natural Products, 2005
- Total Synthesis of Pancratistatin Relying on the [3,3]-Sigmatropic RearrangementThe Journal of Organic Chemistry, 2003
- Toluene Dioxygenase-Mediated cis-Dihydroxylation of Aromatics in Enantioselective Synthesis. Asymmetric Total Syntheses of Pancratistatin and 7-Deoxypancratistatin, Promising Antitumor Agents1Journal of the American Chemical Society, 1996
- Asymmetric Induction in the Metal-Promoted [6.pi. + 2.pi.] Cycloaddition of Azepines. Application to the Construction of Tropane Alkaloids and the Total Synthesis of (+)-FerruginineThe Journal of Organic Chemistry, 1995
- Directed Homogeneous Hydrogenation [New Synthetic Methods (65)]Angewandte Chemie International Edition, 1987
- Stereochemical control of reductions. IV. Control of hydrogenation stereochemistry by intramolecular anionic coordination to homogeneous catalystsJournal of the American Chemical Society, 1974
- Electroreduction of .alpha.,.alpha.'-dibromoketones. 2,4-Dibromo-2,4-dimethyl-3-pentanoneJournal of the American Chemical Society, 1972
- Lycoricidinol and Lycoricidine, New Plant-growth Regulators in the Bulbs of Lycoris radiata HERB.Chemical and Pharmaceutical Bulletin, 1968