A cell culture model using rat coronary artery adventitial fibroblasts to measure collagen production
Open Access
- 8 May 2007
- journal article
- Published by Springer Nature in BMC Cardiovascular Disorders
- Vol. 7 (1) , 13
Abstract
We have developed a rat cell model for studying collagen type I production in coronary artery adventitial fibroblasts. Increased deposition of adventitial collagen type I leads to stiffening of the blood vessel, increased blood pressure, arteriosclerosis and coronary heart disease. Although the source and mechanism of collagen deposition is yet unknown, the adventitia appears to play a significant role. To demonstrate the application of our cell model, cultured adventitial fibroblasts were treated with sex hormones and the effect on collagen production measured.Keywords
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