Bile Salts in Chiral Micellar Electrokinetic Chromatography: 2000–2020
Open Access
Abstract
Bile salts are naturally occurring chiral surfactants that are able to solubilize hydrophobic compounds. Because of this ability, bile salts were exploited as chiral selectors added to the background solution (BGS) in the chiral micellar electrokinetic chromatography (MEKC) of various small molecules. In this review, we aimed to examine the developments in research on chiral MEKC using bile salts as chiral selectors over the past 20 years. The review begins with a discussion of the aggregation of bile salts in chiral recognition and separation, followed by the use of single bile salts and bile salts with other chiral selectors (i.e., cyclodextrins, proteins and single-stranded DNA aptamers). Advanced techniques such as partial-filling MEKC, stacking and single-drop microextraction were considered. Potential applications to real samples, including enantiomeric impurity analysis, were also discussed.Keywords
Funding Information
- Australian Research Council (DP180102810,2018)
This publication has 78 references indexed in Scilit:
- Highly sensitive chiral analysis of amino acids by in-line single drop microextraction and capillary electrophoresis with laser-induced fluorescence detectionAnalytica Chimica Acta, 2010
- Enantiomeric separation of cis‐bifenthrin by CD‐MEKC: Quantitative analysis in a commercial insecticide formulationElectrophoresis, 2010
- Separation of dipeptides with two chiral centers using 2‐hydroxypropyl‐β‐CD‐modified MEKCElectrophoresis, 2010
- Multidimensional Separation of Chiral Amino Acid Mixtures in a Multilayered Three-Dimensional Hybrid Microfluidic/Nanofluidic DeviceAnalytical Chemistry, 2009
- Sodium Cholate Aggregation and Chiral Recognition of the Probe Molecule (R,S)-1,1′-Binaphthyl-2,2′-diylhydrogenphosphate (BNDHP) Observed by 1H and 31P NMR SpectroscopyLangmuir, 2008
- Electrokinetic chromatography with polymeric pseudostationary phasesJournal of Separation Science, 2008
- Proton NMR assignments for R,S‐1,1′‐binaphthol (BN) and R,S‐1,1′‐binaphthyl‐2,2′‐diyl hydrogen phosphate (BNDHP) interacting with bile salt micellesMagnetic Resonance in Chemistry, 2006
- Micellar electrokinetic capillary chromatography determination of (+)S and (−)R arotinolol in serum using UV detection and solid phase extractionChirality, 2001
- Enantioseparation of o-phthaldiadehyde derivatized amino acids using β-CD-modified micellar electrokinetic chromatography in the mixed aqueous-organic mediaAnalytica Chimica Acta, 2001
- Enantiomeric separation of selenoaminoacid derivatives by cyclodextrin-modified micellar electrokinetic chromatography using a mixed micellar system of sodium dodecyl sulphate and taurodeoxycholic acidAnalytica Chimica Acta, 2000