Histamine H 1 Receptor-Mediated Guanosine 3′,5′-Monophosphate Formation by Cultured Mouse Neuroblastoma Cells

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Abstract
Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3′,5′-monophosphate (cyclic GMP) by these cells. Receptor agonists for H 1 , but not H 2 , caused this effect which was reduced by H 1 but not by H 2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H 1 receptors in these cultured nerve cells stimulated cyclic GMP formation.