Antimicrobial susceptibility of Neisseria gonorrhoeae isolated in Durban, South Africa.

Authors:
  • YCY M Coovadia
    Y M Coovadia
  • AKA Kharsany
    A Kharsany
  • URU Ramsaroop
    U Ramsaroop
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Abstract
Clinical isolates of N. gonorrhoeae (140) were screened for production of penicillinase by the intralactam strip method and chromogenic cephalosporin test. Minimum inhibitory concentrations (MIC) of penicillin, ampicillin, tetracycline, cefoxitin, cefuroxime, cefotaxime, sulfamethoxazole-trimethoprim (ratio 19/1) and spectinomycin, were measured for 100 strains by the agar dilution method. Seven (5%) of the 140 isolates were identified as penicillinase-producing N. gonorrhoeae (PPNG). The MIC of penicillin for the 7 PPNG strains ranged from 0.25 mg/l to 2 mg/l. Of the 93 non-PPNG strains, 80 (86%) were fully susceptible to penicillin with MIC ranging from 0.0037 mg/l to 0.06 mg/l and 13 (14%) were of intermediate penicillin resistance with MIC .gtoreq. 0.125 mg/l. Of the 100 isolates tested, 86% were fully susceptible to tetracycline with MIC of < 1 mg/l. No spectinomycin resistant strains were encountered in this study. All gonococcal strains were susceptible to the cephalosporins tested as well as to sulfamethoxazole-trimethoprim.

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