Real‐life experience on effectiveness and tolerability of topical ivermectin in papulopustular rosacea and antiparasitic effect on Demodex mites

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Abstract
Background Ivermectin is a drug approved for the treatment of papulopustular rosacea. Although clinical guidelines recommend the use of ivermectin as the first‐line treatment in patients with almost clear and mild rosacea, studies concerning its use on them are lacking. Objective This study investigated the effectiveness and the tolerability of ivermectin in almost clear to severe rosacea and assessed the anti‐parasitic effect on Demodex mites. Methods This is a retrospective study based on 50 patients affected by papulopustular rosacea and treated with topical ivermectin 1% once daily over 16 weeks. The disease severity, the patient‐examined improvement and the safety assessment of patients were evaluated. Demodex mites were studied with the standardized skin surface biopsy. Results Papulopustular rosacea to all severity achieved a therapeutic success. The number of inflammatory lesions was significantly decreased in almost clear (P<0.0001), mild, moderate and severe (P<0.001) forms. A complete remission of inflammatory lesions was achieved by almost clear (p<0,001) and mild (p=0,005) with 82% with none‐to‐mild cutaneous adverse events. Thirty‐two percent were positive for Demodex mites and all of them turned negative after 16 weeks. Conclusion Ivermectin is an effective treatment not only in moderate‐severe papulopustular rosacea but also in almost clear/mild rosacea.

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