Incarnatapeptins A and B, Nonribosomal Peptides Discovered Using Genome Mining and 1H/15N HSQC-TOCSY
Authors:
- Kalindi D. MorganKMKalindi D. Morgan
- David E. WilliamsDWDavid E. Williams
- Brian O. PatrickBPBrian O. Patrick
- Marion RemigyMRMarion Remigy
- Marianne D. SadarMSMarianne D. Sadar
- Katherine S. RyanKRKatherine S. Ryan
- Raymond J. AndersenRARaymond J. Andersen
- 13 April 2020
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 22 (11) , 4053-4057
Abstract
Methods for the focused isolation of low-abundance natural products with specific chemical substructures could expand known bioactive chemical diversity for drug discovery. Here we report the combined use of genome mining and an 15N NMR-based screening method for the targeted isolation of the low-abundance piperazic-acid-containing peptides incarnatapeptins A (1) and B (3). Incarnatapeptin B (3) shows in vitro cytotoxicity to LNCaP prostate cancer cells.Keywords
Funding Information
- Canadian Institutes of Health Research
- National Cancer Institute (2R01CA105304)
- Natural Sciences and Engineering Research Council of Canada
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