Parathyroid Hormone: Effects of the 3-34 Fragment in Vivo and Vitro
Authors:
- 7 January 1983
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4580) , 67-69
Abstract
The biologically active fragment of parathyroid hormone, consisting of residues 1-34, and its in vitro antagonist, fragment 3-34, were administered separately or in combination to chronically thyroparathyroidectomized dogs. These fragments were also studied in vitro with dog renal cortical membranes. Fragment 3-34 inhibited the stimulation of adenylate cyclase by fragment 1-34 in vitro, but had no agonist or antagonistic effects on renal phosphate transport in vivo.Keywords
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