Efficacy of long-term growth hormone therapy in short children with reduced growth hormone biological activity
- 20 April 2011
- journal article
- Published by Springer Nature in Journal of Endocrinological Investigation
- Vol. 34 (5) , 366-369
Abstract
Aim: The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. Methods: In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height and final stature and the incremental cost-effectiveness ratio. Results: We found a significant (pConclusion: In children with reduced GH biological activity, confirmed by the increase of serum IGF-I levels during generation test, the cost of GH treatment is justified by the positive results obtained in growth and adult height as in classical GHD patients.Keywords
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