The major pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricata.

Authors:
  • NSNoriko Shimizu
    Noriko Shimizu
  • MTMasashi Tomoda
    Masashi Tomoda
  • RGRyoko Gonda
    Ryoko Gonda
  • MKMieko Kanari
    Mieko Kanari
  • NTNoriko Takanashi
    Noriko Takanashi
  • NTNahoko Takahashi
    Nahoko Takahashi
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Abstract
The major acidic polysaccharide, named saposhnikovan A, was isolated from the roots and rhizomes of Saposhnikovia divaricata. It showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 6:15:10, and its molecular weight was estimated to be 54000. About 35% of the D-galacturonic acid residues exist as the methyl esters. Methylation analysis, 13C-nuclear magnetic resonance, and controlled Smith degradation studies indicated that the polysaccharide has the alpha-1----4-linked D-galacturonan backbone bearing alpha-1----5-linked L-arabino-beta-3,6-branched D-galactan side chains.

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