A General and Practical Synthesis of N‐Aryl‐3‐[4‐(imidazol‐4‐yl)‐1,2,3‐triazol‐1‐yl]benzamide Anti‐Inflammatory Cytokine Inhibitors
- 13 May 2014
- journal article
- research article
- Published by Wiley in Asian Journal of Organic Chemistry
- Vol. 3 (7) , 769-772
Abstract
A practical, safe, and efficient synthesis of anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.Keywords
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