Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow

Authors:
Publisher website
Google Scholar
Abstract
Background and Purpose To verify whether the monitoring of regional cerebral oxygen saturation (rSO 2 ) with transcranial near-infrared spectroscopy would successfully reflect changes in intracranial hemodynamics but not changes in extracranial compartment, we measured rSO 2 and regional cerebral blood flow (rCBF) simultaneously in seven patients with cerebral ischemia and five normal volunteers before and after acetazolamide administration. Summary of Report The baseline values of rSO 2 and rCBF were 64.2±5.6% and 53.9±11.1 mL/100 g per minute, respectively. rCBF increased by 44.4±23.3% and rSO 2 significantly increased to 69.6±5.6% after acetazolamide administration. Bilateral simultaneous measurement of rSO 2 indicated a tendency that the larger the ΔrSO 2 , the greater the Δ%rCBF. The relationship between rSO 2 level and rCBF value fit significantly on the theoretical curve calculated from Fick’s equation. Conclusions It is suggested that monitoring of rSO 2 with INVOS-3100 could be a useful indicator in the evaluation of intracranial hemodynamic changes.

This publication has 8 references indexed in Scilit: