Different Roles of the Two High-Oxygen-Affinity Terminal Oxidases of Brucella suis : Cytochrome c Oxidase, but Not Ubiquinol Oxidase, Is Required for Persistence in Mice

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Abstract
The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3 -type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.

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