Does the use of fetal fibronectin in an algorithm for preterm labor reduce triage evaluation times?

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Abstract
Objective: To determine the effectiveness of a novel algorithm based on fetal fibronectin (FFN) for management of preterm labor (PTL). Methods: A randomized trial was performed on patients who presented with symptoms of PTL at 24–34 weeks. Patients were randomized to algorithms with cervical exams only versus cervical exams plus FFN. In this algorithm, physicians had to discharge patients with a negative FFN result. The primary outcome was the evaluation time for triage. The secondary outcomes were admission to the hospital for PTL, preterm birth Results: A total of 76 patients were enrolled and randomized (control n = 32, FFN n = 44). There were no differences in triage time, hospital admissions or preterm deliveries (PTDs) between the two groups. Conclusion: An algorithm based on FFN for management of PTL does not reduce evaluation times for triage, hospital admissions or PTDs.

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