EFFECTS OF KETAMINE ON CENTRAL SYMPATHETIC DISCHARGE AND THE BARORECEPTOR REFLEX DURING MECHANICAL VENTILATION

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Abstract
In rabbits which were ventilated mechanically, with a background anaesthetic of pentobarbitone or after decerebration, ketamine depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response.