Profiling Three-Dimensional Nuclear Telomeric Architecture of Myelodysplastic Syndromes and Acute Myeloid Leukemia Defines Patient Subgroups
Authors:
- Julius Adebayo AweJAJulius Adebayo Awe
- Prerana RodriguesPRPrerana Rodrigues
- Rajat KumarRKRajat Kumar
- Donald S. HoustonDHDonald S. Houston
- Ludger KlewesLKLudger Klewes
- Tandakha Ndiaye DièyeTDTandakha Ndiaye Dièye
- Eduardo Magalhães RegoEREduardo Magalhães Rego
- Roberto Falcão PassettoRPRoberto Falcão Passetto
- Fábio Morato de OliveiraFOFábio Morato de Oliveira
- Sabine MaiSMSabine Mai
Open Access
- 14 June 2012
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 18 (12) , 3293-3304
Abstract
Purpose: Myelodysplastic syndromes (MDS) are a group of disorders characterized by cytopenias, with a propensity for evolution into acute myeloid leukemias (AML). This transformation is driven by genomic instability, but mechanisms remain unknown. Telomere dysfunction might generate genomic instability leading to cytopenias and disease progression.Keywords
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