Association of Parathyroid Tumors in Multiple Endocrine Neoplasia Type 1 with Loss of Alleles on Chromosome 11
Authors:
- Rajesh V. ThakkerRTRajesh V. Thakker
- Pierre BoulouxPBPierre Bouloux
- Carol WoodingCWCarol Wooding
- Kokila ChotaiKCKokila Chotai
- Peter M. BroadPBPeter M. Broad
- Nigel K. SpurrNSNigel K. Spurr
- Gordon M. BesserGBGordon M. Besser
- Jeffrey L.H. O'RiordanJOJeffrey L.H. O'Riordan
- 27 July 1989
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 321 (4) , 218-224
Abstract
Familial multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroid glands, the pancreas, and the pituitary gland. Pancreatic tumors have previously been shown to be associated with the loss of alleles on chromosome 11; we therefore looked for similar genetic alterations in specimens of parathyroid tumors, which are the most common feature of MEN-1.Keywords
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