Tuning Reaction and Diffusion Mediated Degradation of Enzyme‐Sensitive Hydrogels
- 19 January 2016
- journal article
- research article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 5 (4) , 432-438
Abstract
Enzyme‐sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction‐diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design tool for engineering enzyme‐sensitive hydrogels with controlled degradation patterns by tuning the initial hydrogel properties and enzyme kinetics.Keywords
Funding Information
- NIH (1R01AR065441)
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